Hb J-Cubujuqui | alpha141(HC3)Arg->Ser |
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CONTACT | C-terminus | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves to the position of Hb J on starch gel and cellulose acetate at alkaline pH; moves like Hb A on citrate agar | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase A | ||
DNA ANALYSES | Not reported; presumed mutation: CGT->AGT; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity; decreased cooperativity and Bohr effect | ||
STABILITY | Stable | ||
OCCURRENCE | Found in an Indian child living in Costa Rica and in a Mexican American | ||
OTHER INFORMATION | Quantity in heterozygotes 25-29% |
REFERENCES | |||
1. | Saenz, G.F., Elizondo, J., Alvarado, M.A., Atmetlla, F., Arroys, G., Martinez, G., Lima, F., and Colombo, B.: Biochim. Biophys. Acta, 494:48, 1977. | ||
2. | Moo-Penn, W.F., Therrell, B.L., Jr., Jue, D.L., and Johnson, M.H.: Hemoglobin, 5:715, 1981. |