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CONTACT | |
C-terminus | |
HEMATOLOGY | |
Normal in the heterozygote | |
ELECTROPHORESIS | |
Hb X moves to the position of Hb J on starch gel at alkaline pH and by IEF | |
CHROMATOGRAPHY | |
Hb X and Hb A separate by cation and anion exchange chromatography | |
STRUCTURE STUDIES | |
Tryptic digeston; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase A | |
DNA ANALYSES | |
Not reported; presumed mutation CGT->GGT; alpha2 or alpha1 | |
FUNCTIONAL STUDIES | |
Not reported | |
STABILITY | |
Slightly unstable | |
OCCURRENCE | |
Found in a Cuban family of Spanish descent, a Chinese family, a family of Chinese-Australian origin, and a few Spanish families | |
OTHER INFORMATION | |
Quantity in the heterozygotes 18-20% | |
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REFERENCES |
1. | |
Martinez, G., Lima, F., Residenti, C., and Colombo, B.: Hemoglobin, 2:47, 1978. | |
2. | |
Fei, X., Yang, K-G., Liang, C-C., Huang, Y-W., Wang, R-X., and Zhang, N-J.: Hemoglobin, 8:397, 1984. | |
3. | |
Brennan, S.O., Lowrey, I.R., Harris, M.G., Rodwell, R., Zarkos, K., Wilkinson, T., Yakas, J., and Kronenberg, H.: Hemoglobin, 15:303, 1991. | |
4. | |
Romero, M.J., Garrido, M.L., Abril, E., Garrido, F., and de Pablos, J.Ma.: Hemoglobin, 19:287, 1995. | |