Hb Hirosaki | alpha43(CE1)Phe->Leu |
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CONTACT | Heme contact | ||
HEMATOLOGY | Congenital non-spherocytic hemolytic anemia | ||
ELECTROPHORESIS | Hb X and Hb A difficult to separate; Hb X moves with Hb A on agar gel at pH 8.6 and 7.0; data for IEF are not available | ||
CHROMATOGRAPHY | Data for HPLC procedures are not available | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing of a selected peptide | ||
DNA ANALYSES | Not reported; presumed mutation TTC->CTC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in several members of a Japanese (?) family | ||
OTHER INFORMATION | Quantity in heterozygotes difficult to determine; it is estimated at ~10% |
REFERENCES | |||
1. | Ohba, Y., Miyaji, T., Matsuoka, M., Yokoyama, M., Numakura, H., Nagata, K., Takebe, Y., Izumi, Y., and Shibata, S.: Biochim. Biophys. Acta, 405:155, 1975. | ||
2. | Ohba, Y., Miyaji, T., Matsuoka, M., and Yokoyama, M.: Hemoglobin, 2:281, 1978. |