Hb Fort de France | alpha45(CE3)His->Arg |
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CONTACT | External; heme contact | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X and Hb A separate at alkaline pH (moves as Hb S on cellulose acetate); good separation by IEF | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; peptides were separated by fingerprinting or cation exchange chromatography; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CAC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity; normal Bohr effect and cooperativity | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in two unrelated families living in Martinique | ||
OTHER INFORMATION | Quantity in the heterozygote 20%; increased autoxidation |
REFERENCES | |||
1. | Braconnier, F., Gacon, G., Thillet, J., Wajcman, H., Soria, J., Maigret, P., Labie, D., and Rosa, J.: Biochim. Biophys. Acta, 493:228, 1977. |