Hb Fort Worth | alpha27(B8)Glu->Gly |
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CONTACT | External; surface crevice | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb A and Hb S at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by cation exchange chromatography; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->GGG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Inconclusive | ||
OCCURRENCE | Found in a few Black families | ||
OTHER INFORMATION | Quantity in heterozygotes 4-5% |
REFERENCES | |||
1. | Schneider, R.G., Brimhall, B., Jones, R.T., Bryant, R., Mitchell, C.B., and Goldberg, A.I.: Biochim. Biophys. Acta, 243:164, 1971. | ||
2. | Carstairs, K.C., Raulfs, A., Kutlar, A., Chen, S.S., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 9:201, 1985. |