Hb Evanston | alpha14(A12)Trp->Arg |
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CONTACT | Internal | ||
HEMATOLOGY | Mild anemia; microcytosis; associated with alpha-thal-2 | ||
ELECTROPHORESIS | Migrates to the position of Hb S at alkaline pH; no separation from Hb A by citrate agar at acidic pH | ||
CHROMATOGRAPHY | Hb X was isolated by DEAE chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation TGG->AGG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity; Bohr and cooperativity effects normal | ||
STABILITY | Normal | ||
OCCURRENCE | Found in two Black families | ||
OTHER INFORMATION | Quantity in heterozygotes not clearly established |
REFERENCES | |||
1. | Honig, G.R., Shamsuddin, M., Vida, L.N., Mompoint, M., Bowie, L., Jones, E., and Weil, S.: Blood, 60:53a (Suppl. 1), 1982. | ||
2. | Moo-Penn, W.F., Baine, R.M., Jue, D.L., Johnson, M.H., McGuffey, J.E., and Benson, J.M.: Biochim. Biophys. Acta, 747:65, 1983. |