Hb Daneskgah-Tehran | alpha72(EF1)His->Arg |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves to the position of Hb S on cellulose acetate and starch gel at alkaline pH; Hb X moves with Hb A on agar gel at pH 6.2 | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-cellulose column | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting and reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation CAC->CGC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Normal | ||
OCCURRENCE | Found in an Iranian and an Argentinean family | ||
OTHER INFORMATION | Quantity in heterozygotes 25% |
REFERENCES | |||
1. | Rahbar, S., Nowzari, G., and Daneshmond, P.: Nature New Biol., 245:268, 1973. | ||
2. | de Weinstein, B.I., Kutlar, A., Webber, B.B., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 9:409, 1985. |