Hb Dallas | alpha97(G4)Asn->Lys |
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CONTACT | Heme contact | ||
HEMATOLOGY | Mild erythrocytosis in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb A and Hb F on cellulose acetate at alkaline pH; moves slightly anodic to Hb S on citrate agar at acidic pH | ||
CHROMATOGRAPHY | Hb X and Hb A can be separated by cation and anion exchange HPLC | ||
STRUCTURE STUDIES | Tryptic peptides were separated with an HPLC procedure; amino acid analysis | ||
DNA ANALYSES | An AAC->AAA mutation at codon 97 of the alpha2 gene (Ref. 2) | ||
FUNCTIONAL STUDIES | Increased oxygen affinity; normal Bohr, 2,3-DPG, and IHP effects | ||
STABILITY | Stable | ||
OCCURRENCE | Found in a few Caucasian families in the Mid-West (USA) | ||
OTHER INFORMATION | Quantity in heterozygotes 22-23% |
REFERENCES | |||
1. | Dysert, P.A., II, Head, C.G., Shih, T-B., Jones, R.T., and Schneider, R.G.: Blood, 60:53a (Suppl. 1), 1982. | ||
2. | Molchanova, T.P., Pobedimskaya, D.D., and Huisman, T.H.J.: Br. J. Haematol., 88:300, 1994. |