Hb Cordele	alpha47(CE5)Asp->Ala

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slower than Hb S at alkaline pH (cellulose acetate)
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES		The tryptic peptides were separated by reversed phase HPLC; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAC->GCC; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal oxygen affinity
STABILITY		Mildly unstable
OCCURRENCE		Found in a Black family
OTHER INFORMATION		Quantity in heterozygotes 21-23%

REFERENCES
1.		Nakatsuji, T., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 8:37, 1984.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.