Hb Chongqing | alpha2(NA2)Leu->Arg |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Starch gel and cellulose acetate electrophoresis at alkaline pH showed a slowly-moving band corresponding to Hb G | ||
CHROMATOGRAPHY | Hb X can be separated from Hb A by cation and anion exchange chromatography | ||
STRUCTURE STUDIES | Hb X was identified by fingerprinting; peptide alphaT-1 had disappeared and two new peptide spots were observed because of the Leu->Arg substitution at position 2 of the alpha chain | ||
DNA ANALYSES | Not reported; presumed mutation CTG->CGG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Increased oxygen affinity | ||
STABILITY | Unstable | ||
OCCURRENCE | In a Chinese family | ||
OTHER INFORMATION | About 9% in heterozygotes |
REFERENCES | |||
1. | Zeng, Y-T., Huang, S-Z., Qiu, X-K., Cheng, G-C., Ren, Z-R., Jin, Q-C., Chen, C-Y., Jiao, C-T., Tang, Z-G., Liu, R-H., Bao, X-H., Zeng, L-Z., Duan, Y-Q., and Zhang, G-Y.: Hemoglobin, 8:569, 1984. |