Hb F-Macedonia-I	Agamma2(NA2)His->Gln

ELECTROPHORESIS		Hb FX was detected by PAGE
IEF		Not reported
CHROMATOGRAPHY		Not reported
CHAIN SEPARATION		AgammaX = 15%; Ggamma = 70.8%; Agamma = 14.2%
STRUCTURE STUDIES		Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis identified a His-> Glu or Gln change
DNA ANALYSES		A CAT->CAG (His->Gln) mutation at codon 2
NOTES		Found in a healthy Macedonian baby; Hb FX 15% of total Hb F

REFERENCES
1.		Plaseska, D., Cepreganova-Krstik, B., Momirovska, A., and Efremov, G.D.: Hemoglobin, 18:241, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.