Hb F-Jamaica | Agamma61(E5)Lys->Glu |
---|
ELECTROPHORESIS | Hb FX moves much faster than Hb A at alkaline pH; slightly slower than Hb Bart's (or gamma4) | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX was isolated by DEAE-Sephadex and Bio-Rex 70 chromatography | ||
CHAIN SEPARATION | Not reported | ||
STRUCTURE STUDIES | Tryptic digestion of AE-gammaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; se-quencing | ||
DNA ANALYSES | Not reported; presumed mutation AAG->GAG at codon 61 | ||
NOTES | Found in a Jamaican newborn of mixed ethnic origin; Hb FX 11-15% of total Hb F |
REFERENCES | |||
1. | Ahern, E.J., Jones, R.T., Brimhall, B., and Gray, R.H.: Br. J. Haematol., 18:369, 1970. |