Hb F-Calluna | Agamma12(A9)Thr->Arg |
---|
ELECTROPHORESIS | Hb FX moves between Hb S and Hb C at alkaline pH | ||
IEF | Not reported | ||
CHROMATOGRAPHY | Hb FX elutes between Hb A2 and Hb A on a DEAE-cellulose column | ||
CHAIN SEPARATION | AgammaX = 10.7%; Ggamma = 71.5%; AgammaT = 17.8% | ||
STRUCTURE STUDIES | Tryptic digestion of Hb FX; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation ACA->AGA at codon 12 | ||
NOTES | Found in a Caucasian baby; Hb FX 8.7% of total Hb or 10.8% of total Hb F; baby was also heterozygous for the AgammaT chain |
REFERENCES | |||
1. | Nakatsuji, T., Lam, H., and Huisman, T.H.J.: Hemoglobin, 7:563, 1983. |