Table A

TABLE A.

Hematological and Hemoglobin Data (Ref. 1); Black ^Ggamma(^Agammadeltabeta)°-Thalassemia

Family Case Sex-Age Hb Type Hb g/dl PCV l/l RBC 10¹²/l MCV fl MCH pg A₂ % F_AD % alpha/ non- alpha ratio ^Ggamma % # of alpha genes

W-1 W.W. M-50 AF 11.3 0.345 4.83 71.0 23.4 2.55 10.9 1.68 93.8 -alpha/alphaalpha

L.W. F-25 SF 12.8 0.376 4.75 79.0 26.9 2.3 17.3 n.d. 89.8 alphaalpha/alphaalpha

S.W. F-24 AF 13.2 0.400 5.86 68.0 22.5 2.25 11.6 1.73 98.5 -alpha/alphaalpha

B.W. M-21 AF 13.7 0.403 6.63 61.0 20.7 2.45 6.3 1.93 90.0 alphaalpha/alphaalpha

Ba.W.[1] F-19 SF 12.8 0.376 4.75 79.0 26.9 1.8 17.3 0.88 89.8 -alpha/alphaalpha

J.W. M-17 AF 15.1 0.431 6.11 71.0 24.7 2.0 14.6 1.35 91.6 -alpha/alphaalpha

A.W.[1] F-12 SF 11.4 0.452 4.74 75.0 24.1 2.0 21.0 1.71 98.9 alphaalpha/alphaalpha

A M.A. F-40 AF 10.6 0.337 3.46 91.0 30.6 1.8 14.5 1.85 98.8 n.d.

B.A.[1] F-17 SF 9.3 0.285 3.39 83.0 27.4 2.3 21.6 1.93 94.8 alphaalpha/alphaalpha

H.A.[1] F-16 SF 9.2 0.273 3.55 76.0 25.9 2.0 19.2 1.92 95.3 alphaalpha/alphaalpha

I/M R.I.[1] F-45 AF 9.8 0.373 3.89 80.0 25.2 2.75 16.5 n.d. 92.8 -alpha/alphaalpha

M.I.[1] M-17 AF 12.1 0.375 4.26 88.0 28.4 3.1 11.9 1.09 86.8 -alpha/alphaalpha

J.I.[1] M-15 AF 12.6 0.405 5.13 79.0 24.6 3.25 8.4 1.15 86.2 -alpha/alphaalpha

N.I.[1] F-13 AF 11.1 0.325 3.84 85.0 28.9 3.05 15.1 n.d. 86.1 alphaalpha/alphaalpha

F.M. F-19 SF 10.3 0.315 3.75 82.0 27.4 3.1 19.8 n.d. 92.8 n.d.

J.S. F-37 SF 9.4 0.292 3.14 91.0 29.9 2.5 18.3 n.d. 90.3 n.d.

M/C W.B.L.[1] F-35 AF 11.7 0.375 5.07 74.0 23.4 2.3 9.3 n.d. 95.8 -alpha/alphaalpha

J.M.[1] M-15 AF 14.7 0.433 6.12 72.0 24.0 2.0 12.3 0.81 91.2 -alpha/alphaalpha

W.C.C.[1] M-14 AF 13.3 0.395 6.16 66.0 21.6 2.2 4.0 1.38 94.5 -alpha/alphaalpha

J.L.C. M-22 AF 14.2 0.445 6.14 74.0 23.1 2.15 5.2 n.d. 92.8 n.d.

Jl.M. M-12 AF 14.3 0.423 5.00 73.0 23.8 2.1 11.8 n.d. 94.0 n.d.

S W.S.[1] M-42 AF 14.0 0.418 6.36 66.0 22.0 1.8 9.2 n.d. 89.9 alphaalpha/alphaalpha

M.S. M-19 AF 13.6 0.424 5.56 76.0 24.5 1.7 8.5 n.d. 91.9 n.d.

T-1 G.T.[1] F-20 AF 11.8 0.365 4.50 81.0 26.2 2.6 16.2 n.d. 94.6 -alpha/alphaalpha

A.T.[1] M-18 AF 14.5 0.443 5.90 75.0 24.6 2.5 13.3 n.d. 95.0 alphaalpha/alphaalpha

W-2 B.W.[1] F-29 AF 12.2 0.375 5.12 73.0 23.8 2.5 12.7 1.25 87.0 alphaalpha/alphaalpha

G L.G.[1] F-21 AF 10.8 0.320 3.94 81.0 27.4 2.5 15.0 1.34 94.9 alphaalpha/alphaalpha

T-2 M.T.[1] F-31 AF 10.7 0.360 5.16 70.0 20.7 2.0 8.4 n.d. 100.0 alphaalpha/alphaalpha

T.T.[1] F-11 AF 11.0 0.390 5.69 69.0 19.3 2.05 10.0 n.d. 95.3 alphaalpha/alphaalpha

Te.T.[1] F-9 AF 11.6 0.375 5.77 65.0 20.1 1.8 11.1 n.d. 96.4 alphaalpha/alphaalpha

L I.L.[1] M-20+ AF 14.5 0.475 5.72 74.0 25.3 2.6 11.9 1.18 100.0 alphaalpha/alphaalpha

Family	Case	Sex-Age	Hb Type	Hb g/dl	PCV l/l	RBC 10¹²/l	MCV fl	MCH pg	A₂ %	F_AD %	alpha/ non- alpha ratio	^Ggamma %	# of alpha genes

W-1	W.W.	M-50	AF	11.3	0.345	4.83	71.0	23.4	2.55	10.9	1.68	93.8	-alpha/alphaalpha
	L.W.	F-25	SF	12.8	0.376	4.75	79.0	26.9	2.3	17.3	n.d.	89.8	alphaalpha/alphaalpha
	S.W.	F-24	AF	13.2	0.400	5.86	68.0	22.5	2.25	11.6	1.73	98.5	-alpha/alphaalpha
	B.W.	M-21	AF	13.7	0.403	6.63	61.0	20.7	2.45	6.3	1.93	90.0	alphaalpha/alphaalpha
	Ba.W.[1]	F-19	SF	12.8	0.376	4.75	79.0	26.9	1.8	17.3	0.88	89.8	-alpha/alphaalpha
	J.W.	M-17	AF	15.1	0.431	6.11	71.0	24.7	2.0	14.6	1.35	91.6	-alpha/alphaalpha
	A.W.[1]	F-12	SF	11.4	0.452	4.74	75.0	24.1	2.0	21.0	1.71	98.9	alphaalpha/alphaalpha

A	M.A.	F-40	AF	10.6	0.337	3.46	91.0	30.6	1.8	14.5	1.85	98.8	n.d.
	B.A.[1]	F-17	SF	9.3	0.285	3.39	83.0	27.4	2.3	21.6	1.93	94.8	alphaalpha/alphaalpha
	H.A.[1]	F-16	SF	9.2	0.273	3.55	76.0	25.9	2.0	19.2	1.92	95.3	alphaalpha/alphaalpha

I/M	R.I.[1]	F-45	AF	9.8	0.373	3.89	80.0	25.2	2.75	16.5	n.d.	92.8	-alpha/alphaalpha
	M.I.[1]	M-17	AF	12.1	0.375	4.26	88.0	28.4	3.1	11.9	1.09	86.8	-alpha/alphaalpha
	J.I.[1]	M-15	AF	12.6	0.405	5.13	79.0	24.6	3.25	8.4	1.15	86.2	-alpha/alphaalpha
	N.I.[1]	F-13	AF	11.1	0.325	3.84	85.0	28.9	3.05	15.1	n.d.	86.1	alphaalpha/alphaalpha
	F.M.	F-19	SF	10.3	0.315	3.75	82.0	27.4	3.1	19.8	n.d.	92.8	n.d.
	J.S.	F-37	SF	9.4	0.292	3.14	91.0	29.9	2.5	18.3	n.d.	90.3	n.d.

M/C	W.B.L.[1]	F-35	AF	11.7	0.375	5.07	74.0	23.4	2.3	9.3	n.d.	95.8	-alpha/alphaalpha
	J.M.[1]	M-15	AF	14.7	0.433	6.12	72.0	24.0	2.0	12.3	0.81	91.2	-alpha/alphaalpha
	W.C.C.[1]	M-14	AF	13.3	0.395	6.16	66.0	21.6	2.2	4.0	1.38	94.5	-alpha/alphaalpha
	J.L.C.	M-22	AF	14.2	0.445	6.14	74.0	23.1	2.15	5.2	n.d.	92.8	n.d.
	Jl.M.	M-12	AF	14.3	0.423	5.00	73.0	23.8	2.1	11.8	n.d.	94.0	n.d.

S	W.S.[1]	M-42	AF	14.0	0.418	6.36	66.0	22.0	1.8	9.2	n.d.	89.9	alphaalpha/alphaalpha
	M.S.	M-19	AF	13.6	0.424	5.56	76.0	24.5	1.7	8.5	n.d.	91.9	n.d.

T-1	G.T.[1]	F-20	AF	11.8	0.365	4.50	81.0	26.2	2.6	16.2	n.d.	94.6	-alpha/alphaalpha
	A.T.[1]	M-18	AF	14.5	0.443	5.90	75.0	24.6	2.5	13.3	n.d.	95.0	alphaalpha/alphaalpha

W-2	B.W.[1]	F-29	AF	12.2	0.375	5.12	73.0	23.8	2.5	12.7	1.25	87.0	alphaalpha/alphaalpha

G	L.G.[1]	F-21	AF	10.8	0.320	3.94	81.0	27.4	2.5	15.0	1.34	94.9	alphaalpha/alphaalpha

T-2	M.T.[1]	F-31	AF	10.7	0.360	5.16	70.0	20.7	2.0	8.4	n.d.	100.0	alphaalpha/alphaalpha
	T.T.[1]	F-11	AF	11.0	0.390	5.69	69.0	19.3	2.05	10.0	n.d.	95.3	alphaalpha/alphaalpha
	Te.T.[1]	F-9	AF	11.6	0.375	5.77	65.0	20.1	1.8	11.1	n.d.	96.4	alphaalpha/alphaalpha

L	I.L.[1]	M-20+	AF	14.5	0.475	5.72	74.0	25.3	2.6	11.9	1.18	100.0	alphaalpha/alphaalpha

[1] The (^Agammadeltabeta)°-thal was identified in this person through analysis of the DNA.

This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.