TABLE XIV.   Beta-Thalassemia Alleles in Japanese and Korean Beta-Thalassemia Heterozygotes (number of chromosomes) (references in parentheses)

Allele Japan
(1,2) 		Korea
(2) 		Allele Japan
(1,2) 		Korea
(2)
-31, A->G 45   Codon 40, -G 1  
-28, A->G 1   Codons 41/42, -TTCT 19 1
Initiation codon, ATG->ACG 2   Codons 42/43, +T 1  
Initiation codon, ATG->AGG 5 7 Codons 42/43, +G 1  
Initiation codon, ATG->ATA 5   Codons 53/54, +G 2  
Initiation codon, ATG->ATC 2   Codons 84/85, +C 3  
Initiation codon, ATG->GTG 11   Codons 84/85/86, +T 6  
Codons 8/9, +G 2   Codons 89/90, -GT   7
Codon 15, TGG->TAG 3   Codon 90, G->T 44  
Codon 15, TGG->TGA 3   IVS-II-1, G->A 29 1
Codon 17, AAG->TAG 1 4 IVS-II-654, C->T 38  
Codon 24, T->A 2   IVS-II-848, C->G 2  
Codons 28/29, -G 1   IVS-II-850, G->A 2  
IVS-I-1, G->T 3   IVS-II-850, G->T 1  
IVS-I-130, G->A   1 Codon 110, T->C 3  
IVS-I-130, G->C 1 1 Codon 121, G->T 7 1
Codons 33/34, -GTG   1 Codon 123, -A 1  
Codon 35, C->A 1   Codon 125, -A 1  
Codon 39, C->T 1   Codons 127/128, -AGG 11  
      TOTAL 261 18

1. Hattori, Y., Yamane, A., Yamashiro, Y., Matsuno, Y., Yamamoto, Ki., Yamamoto, Ku., Ohba, Y., and Miyaji, T.: Hemoglobin, 13:657, 1989.
2. Ohba, Y., Hattori, Y., Harano, T., Harano, K., Fukumaki, Y., Ideguchi, H., Cho, H.I., and Park, S.S.: Hemoglobin, 21:191, 1997.

This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.