Table IV

TABLE IV.

Beta-Thalassemia Alleles in Greeks and Greek Cypriots (number of chromosomes) (references in parentheses)

Allele Greek Pediatric
Patients (1) Greek Adult
Patients (2) Greek Cypriot
Patients (3) Total %

-101, C->T 3 3 0.18

-87, C->G 6 13 19 1.12

-30, T->A 1 1 0.06

Codon 5, -CT 4 2 6 0.35

Codon 6, -A 10 18 1 29 1.71

Codon 8, -AA 2 7 2 11 0.65

Codons 8/9, +G 1 1 0.06

IVS-I-1, G->A 46 89 36 171 10.09

IVS-I-5, G->A 3 3 0.18

IVS-I-6, T->C 25 56 39 120 7.08

IVS-I-110, G->A 148 277 563 988 58.32

Codon 39, C->T 59 134 20 213 12.57

IVS-II-1, G->A 7 13 20 1.18

IVS-II-745, C->G 24 19 36 79 4.72

IVS-II-848, C->A 2 2 0.12

AATAAA->AATGAA 1 1 0.06

44 bp deletion 2 2 0.12

Hb Lepore 3 3 0.18

Unknown; others 4 10 8 22 1.30

TOTAL 348 641 705 1694

Allele	Greek Pediatric Patients (1)	Greek Adult Patients (2)	Greek Cypriot Patients (3)	Total	%
-101, C->T		3		3	0.18
-87, C->G	6	13		19	1.12
-30, T->A	1			1	0.06
Codon 5, -CT	4	2		6	0.35
Codon 6, -A	10	18	1	29	1.71
Codon 8, -AA	2	7	2	11	0.65
Codons 8/9, +G	1			1	0.06
IVS-I-1, G->A	46	89	36	171	10.09
IVS-I-5, G->A	3			3	0.18
IVS-I-6, T->C	25	56	39	120	7.08
IVS-I-110, G->A	148	277	563	988	58.32
Codon 39, C->T	59	134	20	213	12.57
IVS-II-1, G->A	7	13		20	1.18
IVS-II-745, C->G	24	19	36	79	4.72
IVS-II-848, C->A	2			2	0.12
AATAAA->AATGAA	1			1	0.06
44 bp deletion	2			2	0.12
Hb Lepore	3			3	0.18
Unknown; others	4	10	8	22	1.30
TOTAL	348	641	705	1694

1. Kattamis, C., Hu, H., Cheng, G., Reese, A.L., Gonzalez-Redondo, J.M., Kutlar, A., Kutlar, F., and Huisman, T.H.J.: Br. J. Haematol., 74:342, 1990.

2. Kollia, P., Karababa, Ph., Sinopoulou, K., Voskaridou, E., Boussiou, M., Papadakis, M., and Loukopoulos, D.: Gene Geogr., 6:59, 1992.

3. Baysal, E., Indrak, K., Bozkurt, G., Berkalp, A., Aritkan, E., Old, J.M., Ioannou, P., Angastiniotis, M., Droushiotou, A., Yüregir, G.T., Kilinç, Y., and Huisman, T.H.J.: Br. J. Haematol., 81:607, 1992.

This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.

1.	Kattamis, C., Hu, H., Cheng, G., Reese, A.L., Gonzalez-Redondo, J.M., Kutlar, A., Kutlar, F., and Huisman, T.H.J.: Br. J. Haematol., 74:342, 1990.
2.	Kollia, P., Karababa, Ph., Sinopoulou, K., Voskaridou, E., Boussiou, M., Papadakis, M., and Loukopoulos, D.: Gene Geogr., 6:59, 1992.
3.	Baysal, E., Indrak, K., Bozkurt, G., Berkalp, A., Aritkan, E., Old, J.M., Ioannou, P., Angastiniotis, M., Droushiotou, A., Yüregir, G.T., Kilinç, Y., and Huisman, T.H.J.: Br. J. Haematol., 81:607, 1992.