MUTATION		~27 kb deletion (see Fig. 4); the Southeast Asian (SEA) deletion
AMINO ACID REPLACEMENT		None
TYPE OF BETA-THAL		beta°
MECHANISM		No beta chain production; greatly increased gamma chain synthesis
IDENTIFICATION		Gene mapping
HEMATOLOGY IN HETEROZYGOTE(S)		Hb 11.4-16.2 g/dl; MCV 76-80 fl; MCH 21.6-26.2 pg; Hb A2 4.1, 4.0, 5.1, 4.1, 4.8%; Hb F 20.1, 23.8, 16.8, 20.5, 14.1%
HEMATOLOGY IN HOMOZYGOTE(S)		None
OCCURRENCE		In a few Vietnamese, Cambodian, and Chinese families
HAPLOTYPE		Not determined
FOUND IN COMBINATION WITH ABNORMAL HB(S)		None
FOUND IN COMBINATION WITH BETA-THAL ALLELE(S)		None
OTHER INFORMATION		The deletion includes the entire beta-globin gene

REFERENCES
1.		Dimovski, A.J., Divoky, V., Adekile, A.D., Baysal, E., Wilson, J.B., Prior, J.F., Raven, J.L., and Huisman, T.H.J.: Blood, 83:822, 1994.

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This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.