V.   The (DeltaBeta)°-Thalassemias

This group of conditions is characterized by deletions involving at least part of the delta- and beta-globin genes. Often the deletion is much larger and includes the entire delta and beta genes, and sometimes the Agamma or the Agamma, Ggamma, and epsilon genes. The phenotype of the heterozygote is comparable to that of a beta°-thal. Four different groups are recognized:

V-a.   The GgammaAgamma(deltabeta)°-thal alleles;
V-b.   The Lepore Hbs;
V-c.   The Ggamma(Agammadeltabeta)°-thal alleles;
V-d.   The (epsilongammadeltabeta)°-thal alleles.
(Globin genes listed between parentheses are part of the deletion.)

This material is from the book A Syllabus of Thalassemia Mutations (1997) by Titus H.J. Huisman, Marianne F.H. Carver, and Erol Baysal, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1997 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without permission in writing from the Author.