Minimal Evolutionary Change Regions Locating Utility

Regions of minimal evolutionary change will be determined in the multiple alignment as the corresponding positions in the "human" sequence.   More information

The alignment to be used is: Old beta-globin alignment New beta-globin alignment .

This alignment will be examined from: to: in "human",

and these offsets are relative to:		The beginning of the human sequence file
		The beginning of GenBank's HUMHBB locus.

(NOTES:   If you have chosen to use the "Old beta-globin alignment", then these two origins are the same, while the "New beta-globin alignment" begins 2687 bp 5' to HUMHBB. The output is always labeled relative to the beginning of the sequence files used in the alignment.)

The anchor value from which the minimal number of changes should be subtracted will be established as:

• Number of active rows in the column
• Number of active rows not containing a gap in the column
• Zero (no flexible anchors)

Furthermore, constant value will be added to the anchor value for any column (this is in addition to calculated flexible anchor, if any).

Minimal length of a region necessary for it to be recognized is: .

Minimal number of sequences which must be active (already started and not yet ended) within a region must be: .

Please choose the method of gap treatment:

• General (gaps are ordinary characters)
• Strict (gaps prohibited within regions)
• Wildcard (gaps are wildcard characters)
• Mandatory (gaps must be placed at ancestor)
• Promoted (gaps must mask character at ancestor)
• Prohibited (gaps must not be placed at ancestor)
• Masked (gaps at ancestor must be masked)

The results of this tool should be presented as:

List Image

Press to determine the regions, or to restore defaults.