Hb Tours	beta87(F3)Thr->0

HEMATOLOGY		Mild hemolytic anemia in the heterozygote
ELECTROPHORESIS		Hb X moves like Hb S at alkaline pH
CHROMATOGRAPHY		Hb X was isolated on a cation exchange (Bio-Rex 70) column
STRUCTURE STUDIES		Tryptic digestion of AE-betaX chain; separation of peptides by cation exchange chromatography; amino acid analysis; sequencing
DNA ANALYSES		Not reported
FUNCTION STUDIES		Increased oxygen affinity; the unstable Hb readily loses heme
STABILITY		Unstable
OCCURRENCE		Found in a 40-year-old French male
OTHER INFORMATION		Quantity in the heterozygote about 25%

REFERENCES
1.		Najman, A., Duhamel, G., Andre, R., Buc, H., Wajcman, H., Labie, D., and Schapira, G.: Nouv. Rev. Fr. d'Hematol., 13:803, 1973.
2.		Wajcman, H., Labie, D., and Schapira, G.: Biochim. Biophys. Acta, 295:495, 1973.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.