Hb Lincoln Park | betadelta hybrid (beta through 22; delta from 50)as in Hb P-Nilotic |
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but with the deletion of a valine residue at delta137 |
HEMATOLOGY | Mild hemolytic anemia; reticulocytosis | ||
ELECTROPHORESIS | Hb X moves slightly faster than Hb S at alkaline pH; and by IEF | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Tryptic digestion of AE-betadelta chain; separation of peptides by cation exchange chromatography; amino acid analysis; Edman PTH degradation | ||
DNA ANALYSES | Not reported; presumably a P-Nilotic betadelta gene with an additional deletion of a GTG triplet at codon 137 | ||
FUNCTION STUDIES | Normal oxygen affinity | ||
STABILITY | Normal | ||
OCCURRENCE | Found in members of a family in Southern Mexico | ||
OTHER INFORMATION | Quantity in the heterozygote 14%; decreased globin chain synthesis in reticulocytosis |
REFERENCES | |||
1. | Honig, G.R., Shamsuddin, M., Mason, R.G., and Vida, L.N.: Proc. Natl. Acad. Sci. USA, 75:1475, 1978. | ||
2. | Honig, G.R., Mason, R.G., Tremaine, L.M., and Vida, L.N.: Am. J. Hematol., 5:335, 1978. |