Hb F-Lodz | Ggamma44(CD3)Ser->Arg |
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ELECTROPHORESIS | Hb FX moves between Hb S and Hb C at alkaline pH | ||
IEF | Same as above | ||
CHROMATOGRAPHY | Not reported | ||
CHAIN SEPARATION | GgammaX+AgammaT = 61.2%; Ggamma = 25.6%; Agamma = 13.2% | ||
STRUCTURE STUDIES | Tryptic digestion of gammaX chain; separation of peptides by reversed phase HPLC; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation AGC->CGC at codon 44 | ||
NOTES | Found in a Polish newborn; Hb FX 37.1% of total Hb |
REFERENCES | |||
1. | Honig, G.R., Koshy, M., Schroeder, W.A., Shelton, J.B., and Shelton, J.R.: Biochim. Biophys. Acta, 707:213, 1982. | ||
2. | Cepreganova, B., Gu, L-H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 15: 549, 1991. |