Hb A2-Parkville	delta47(CD6)Asp->Val

CONTACT		External
ELECTROPHORESIS		Hb X moves like Hb S at alkaline pH
IEF		Not reported
CHROMATOGRAPHY		Hb X was isolated by DEAE-Sephadex chromatography
STRUCTURE ANALYSIS		Digestion of deltaX with trypsin; separation of peptides by reversed phase HPLC; sequencing
DNA ANALYSIS		Not reported; presumed mutation GAT->GTT at codon 47
NOTES		Found in members of an Italian family; probably occurred in combination with beta-thal

REFERENCES
1.		Leung, H., Gilbert, A.T., Fleming, P.J., Wong, J., Hughes, W.G., Hussein, S., and Nash, A.R.: Hemoglobin, 15:407, 1991.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.