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CONTACT | |
Internal | |
HEMATOLOGY | |
Normal in the heterozygote | |
ELECTROPHORESIS | |
Hb X and Hb A can be separated at alkaline pH; Hb X moves slower than Hb A | |
CHROMATOGRAPHY | |
Hb X elutes after Hb A on a CM-cellulose column | |
STRUCTURE STUDIES | |
Tryptic digestion; separation of peptides by fingerprinting or cation exchange chromatography; amino acid analysis; sequencing | |
DNA ANALYSES | |
Not reported; presumed mutation GTG->CTG at codon 60 | |
FUNCTION STUDIES | |
Not reported | |
STABILITY | |
Not reported | |
OCCURRENCE | |
Found in a Japanese individual | |
OTHER INFORMATION | |
Quantity in the heterozygote 45%; the electrophoretic and chromatographic separation of Hb X and Hb A is surprising; reevaluation of this variant is desirable; perhaps there is an additional amino acid replacement that was overlooked | |