Hb Riverdale-Bronx	beta24(B6)Gly->Arg

CONTACT		Internal; close contact with the E helix
HEMATOLOGY		Mild hemolytic anemia with reticulocytosis in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X takes the position of Hb S
CHROMATOGRAPHY		Hb X was isolated by DEAE-cellulose chromatography
STRUCTURE STUDIES		Tryptic digestion; fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GGT->CGT at codon 24
FUNCTION STUDIES		Increased oxygen affinity; normal Bohr effect, and cooperativity
STABILITY		Unstable
OCCURRENCE		Found in a female of German-Jewish ancestry
OTHER INFORMATION		Quantity in the heterozygote 30%; splenomegaly present

REFERENCES
1.		Ranney, H.M., Jacobs, A.S., Uden, L., and Zalusky, R.: Biochem. Biophys. Res. Commun., 33:1004, 1968.
2.		Bank, A., O'Donnell, J.V., and Braverman, A.S.: J. Lab. Clin. Med., 76:616, 1970.
3.		Farace, M.G. and Bank, A.: Biochim. Biophys. Acta, 312:591, 1973.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.