Hb Yuda	alpha130(H13)Ala->Asp

CONTACT		Internal; central cavity
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X has a pI nearly the same as Hb A1c on IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		The alphaX chain was isolated by CM-cellulose chromatography; tryptic digestion; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GCT->GAT; alpha2 or alpha1
FUNCTIONAL STUDIES		Decreased oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in a diabetic Japanese female
OTHER INFORMATION		The alphaX chain accounts for ~30% of total alpha

REFERENCES
1.		Fujisawa, K., Hattori, Y., Ohba, Y., and Ando, S.: Hemoglobin, 16:435, 1992.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.