Hb Valparaiso	alpha88(F9)Ala->Gly

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X focuses at a pI slightly higher than Hb A and migrates between Hb A and Hb F on cellulose acetate; Hb X and Hb A can be separated by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Hb X was isolated by preparative IEF and digested with trypsin; tryptic peptides were separated by reversed phase HPLC; amino acid analysis; peptide alphaXT-9 was digested with protease V8
DNA ANALYSES		Not reported; presumed mutation GCG->GGG; alpha2 or alpha1
FUNCTIONAL STUDIES		Slight increase in oxygen affinity
STABILITY		Not reported
OCCURRENCE		Found in members of a Chilean family
OTHER INFORMATION		Quantity in the heterozygote ~27%

REFERENCES
1.		Wajcman, H., de Montalembert, M., Girot, R., Kister, J., Maier-Redelsperger, M., and Galacteros, F.: Hemoglobin, 18:275, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.