Hb Ube-4	alpha116(GH4)Glu->Ala

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves slightly faster than Hb S at alkaline pH
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAG->GCG; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in a Japanese and a Korean family
OTHER INFORMATION		Quantity in heterozygotes 10-15%

REFERENCES
1.		Ohba, Y., Miyaji, T., Matsuoka, M., Morito, M., and Iuchi, I.: Hemoglobin, 2:181, 1978.
2.		Iuchi, I., Hidaka, K., Ueda, S., Shibata, S., Hitomi, F., and Takesue, A.: Hemoglobin, 2:561, 1978.
3.		Hidaka, K., Iuchi, I., Ueda, S., Shibata, S., Hitomi, F., and Takesue, A.: Kawasaki Med. J., 4:271, 1978.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.