Hb Ube-4 | alpha116(GH4)Glu->Ala |
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CONTACT | External | ||
HEMATOLOGY | Normal in the heterozygote | ||
ELECTROPHORESIS | Hb X moves slightly faster than Hb S at alkaline pH | ||
CHROMATOGRAPHY | Hb X was isolated on a DEAE-Sephadex column | ||
STRUCTURE STUDIES | Fingerprinting; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GAG->GCG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Normal | ||
STABILITY | Normal | ||
OCCURRENCE | Found in a Japanese and a Korean family | ||
OTHER INFORMATION | Quantity in heterozygotes 10-15% |
REFERENCES | |||
1. | Ohba, Y., Miyaji, T., Matsuoka, M., Morito, M., and Iuchi, I.: Hemoglobin, 2:181, 1978. | ||
2. | Iuchi, I., Hidaka, K., Ueda, S., Shibata, S., Hitomi, F., and Takesue, A.: Hemoglobin, 2:561, 1978. | ||
3. | Hidaka, K., Iuchi, I., Ueda, S., Shibata, S., Hitomi, F., and Takesue, A.: Kawasaki Med. J., 4:271, 1978. |