Hb Tokoname	alpha139(HC1)Lys->Thr

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X is more anodic than Hb A by IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin
DNA ANALYSES		Not reported; presumed mutation AAA->ACA; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity; decreased cooperativity; normal Bohr effect
STABILITY		Normal
OCCURRENCE		Found in a Japanese female
OTHER INFORMATION		Quantity in the heterozygote about 25%

REFERENCES
1.		Harano, T., Harano, K., Shibata, S., Ueda, S., Imai, K., and Seki, M.: Hemoglobin, 7:85, 1983.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.