Hb Tatras	alpha7(A5)Lys->Asn

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Electrophoresis at alkaline pH showed a fast-moving Hb like Hb A1c
CHROMATOGRAPHY		A fast-moving Hb component was separated from Hb A by cation exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; the peptides were separated by reversed phase HPLC; peptides alphaT-1 and alphaT-2 combined to form an alphaT-1,2 peptide; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation AAG->AAC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a 72-year-old woman born in Czechoslovakia
OTHER INFORMATION		Quantity in the heterozygote 22%

REFERENCES
1.		Wajcman, H., Bost, M., Blouquit, Y., Préhu, C., Riou, J., and Galacteros, F.: Hemoglobin, 18:427, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.