Hb Suresnes	alpha141(HC3)Arg->His

CONTACT		C-terminus
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb J on cellulose acetate at alkaline pH; has a pI of 6.91 on IEF (Hb A 6.95)
CHROMATOGRAPHY		Hb X was isolated by anion exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting or cation exchange chromatography; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CGT->CAT; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity; decreased cooperativity and Bohr effect
STABILITY		Not reported
OCCURRENCE		Found in a French and a Black family
OTHER INFORMATION		Quantity in heterozygotes 22-25%

REFERENCES
1.		Poyart, C., Krishnamoorthy, R., Bursaux, E., Gacon, G., and Labie, D.: FEBS Lett., 69:103, 1976.
2.		Bursaux, E., Krishnamoorthy, R., Poyart, C., and Bohn, B.: INSERM, 70:277, 1977.
3.		Poyart, C., Bursaux, E., Arnone, A., Bonaventura, J., and Bonaventura, C.: J. Biol. Chem., 255:9465, 1980.
4.		Gravely, M.E., Harris, H.F., Stallings, M., Lam, H., Wilson, J.B., and Huisman, T.H.J.: Hemoglobin, 2:187, 1978.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.