Hb Suan-Dok	alpha109(G16)Leu->Arg

CONTACT		Internal
HEMATOLOGY		Mild alpha-thal with microcytosis and hypochromia in the heterozygote
ELECTROPHORESIS		Hb X moves slower than Hb F at alkaline pH and by IEF
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		A CTG->CGG mutation at codon 109 of the alpha2 gene (Ref. 2)
FUNCTIONAL STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in a Thai female
OTHER INFORMATION		Quantity in the heterozygote 8.8%; found in combination with alpha-thal-1 to give Hb H disease

REFERENCES
1.		Sanguansermsri, T., Matragoon, S., Changloah, L., and Flatz, G.: Hemoglobin, 2:161, 1979.
2.		Hundrieser, J., Sanguansermsri, T., Laig, M., Pape, M., Kuhnau, W., and Flatz, G.: Hemoglobin, 14:69, 1990.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.