Hb Strumica	alpha112(G19)His->Arg

ALSO KNOWN AS		Serbia
CONTACT		External
HEMATOLOGY		Nearly normal in the heterozygote; slight hemolysis
ELECTROPHORESIS		Hb X moves to the position of Hb Lepore at alkaline pH
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic and chymotryptic peptides separated by cation exchange chromatography or by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CAC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a few Serbian, Turkish, and Macedonian families
OTHER INFORMATION		Quantity in heterozygotes 16-17%

REFERENCES
1.		Niazi, G.A., Efremov, G.D., Nikolov, N., Hunter, E., Jr., and Huisman, T.H.J.: Biochim. Biophys. Acta, 412:181, 1975.
2.		Beksedic, D., Rajevska, T., Lorkin, P.A., and Lehmann, H.: FEBS Lett., 58: 226, 1975.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.