Hb St. Claude	alpha127(H10)Lys->Thr

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves faster than Hb A at alkaline pH
CHROMATOGRAPHY		Hb X and Hb A separate by cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by cation exchange chromatography; performic acid, chymotrypsin; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation AAG->ACG; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a family of French-Canadian descent
OTHER INFORMATION		Quantity in the heterozygote 27-29%

REFERENCES
1.		Vella, F., Galbraith, P., Wilson, J.B., Wong, S.C., Folger, G.C., and Huisman, T.H.J.: Biochim. Biophys. Acta, 365:318, 1974.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.