Hb Singapore	alpha141(HC3)Arg->Pro

CONTACT		C-terminus
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb J-Baltimore at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; chymotrypsin
DNA ANALYSES		Not reported; presumed mutation CGT->CCT; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in members of a family living in Singapore
OTHER INFORMATION		Quantity in heterozygotes about 25%

REFERENCES
1.		Clegg, J.B., Weatherall, D.J., Wong, H.B., and Mustafa, D.: Nature, 222:379, 1969.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.