Hb Shuangfeng | alpha27(B8)Glu->Lys |
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CONTACT | External; surface crevice | ||
HEMATOLOGY | Hemolytic anemia in the heterozygote | ||
ELECTROPHORESIS | Hb X moves between Hb S and Hb C on cellulose acetate (pH 8.6); moves with Hb A on citrate agar (pH 6.0) | ||
CHROMATOGRAPHY | Hb X was isolated by DE-52 cellulose chromatography | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->AAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in six members of a Chinese family | ||
OTHER INFORMATION | Quantity in heterozygotes about 13% |
REFERENCES | |||
1. | Liang, C., Tao, H., Lo, H., Huang, S., Li, R., and Wang, B.: Hemoglobin, 5:691, 1981. |