Hb Russ	alpha51(CE9)Gly->Arg

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; moves as Hb S on starch gel
CHROMATOGRAPHY		Hb X and Hb A can be separated by cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic peptides of the alpha chain were separated by cation exchange chromatography; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GGC->CGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in Caucasian families in the USA and in a Chinese family
OTHER INFORMATION		Quantity in heterozygotes 10-13%

REFERENCES
1.		Reynolds, C.A. and Huisman, T.H.J.: Biochim. Biophys. Acta, 130:541, 1966.
2.		Chen, S-S., Yang, K-G., Jia, P-C., Liang, C-C., Huang, S-L., Liang, J-T., Chen, Q., and Li, H-H.: Acta Biochim. Biophys. Sin., 15(4):339, 1983.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.