Hb Port Phillip	alpha91(FG3)Leu->Pro

CONTACT		Heme and alpha1beta2 contacts
HEMATOLOGY		Mild anemia; reticulocytosis in the heterozygote
ELECTROPHORESIS		Hb X moves to the position of Hb F on starch gel at alkaline pH
CHROMATOGRAPHY		Hb X and Hb A separate incompletely on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CTT->CCT; alpha2 or alpha1T
FUNCTIONAL STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in a Chinese female
OTHER INFORMATION		Quantity in the heterozygote about 7%

REFERENCES
1.		Brennan, S.O., Tauro, G.P., Melrose, W., and Carrell, R.W.: FEBS Lett., 81:115, 1977.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.