Hb Petah Tikva | alpha110(G17)Ala->Asp |
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CONTACT | Internal | ||
HEMATOLOGY | Near normal in the heterozygote | ||
ELECTROPHORESIS | No separation of Hb X and Hb A at alkaline pH | ||
CHROMATOGRAPHY | No separation of Hb X and Hb A by DEAE-cellulose or DEAE-Sephadex chromatography | ||
STRUCTURE STUDIES | The alphaX and alphaA chains separate in CM-cellulose chromatography; tryptic and chymotryptic peptides separated by column chromatography; amino acid analysis; sequencing | ||
DNA ANALYSES | Not reported; presumed mutation GCC->GAC; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Unstable | ||
OCCURRENCE | Found in a few families of Iraqi Jews | ||
OTHER INFORMATION | Found in combination with alpha-thal-1 to give Hb H disease |
REFERENCES | |||
1. | Honig, G.R., Shamsuddin, M., Zaizov, R., Steinherz, M., Solar, I., and Kirschmann, C.: Blood, 57:705, 1981. |