Hb Petah Tikva	alpha110(G17)Ala->Asp

CONTACT		Internal
HEMATOLOGY		Near normal in the heterozygote
ELECTROPHORESIS		No separation of Hb X and Hb A at alkaline pH
CHROMATOGRAPHY		No separation of Hb X and Hb A by DEAE-cellulose or DEAE-Sephadex chromatography
STRUCTURE STUDIES		The alphaX and alphaA chains separate in CM-cellulose chromatography; tryptic and chymotryptic peptides separated by column chromatography; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GCC->GAC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Unstable
OCCURRENCE		Found in a few families of Iraqi Jews
OTHER INFORMATION		Found in combination with alpha-thal-1 to give Hb H disease

REFERENCES
1.		Honig, G.R., Shamsuddin, M., Zaizov, R., Steinherz, M., Solar, I., and Kirschmann, C.: Blood, 57:705, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.