Hb Perspolis	alpha64(E13)Asp->Tyr

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline and acidic pH; Hb X moves slightly faster than Hb D on cellulose acetate and starch gel
CHROMATOGRAPHY		Hb X can be isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; sequencing
DNA ANALYSES		Not reported; presumed mutation GAC->TAC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in an Indian Sikh
OTHER INFORMATION		Quantity in the heterozygote 20%

REFERENCES
1.		Rahbar, S., Ala, F., Akhavan, E., Nowzari, G., Shoa'l, I., and Zamanianpoor, M.H.: Biochim. Biophys. Acta, 427:119, 1976.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.