Hb Ottawa	alpha15(A13)Gly->Arg

ALSO KNOWN AS		Siam
CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves close to Hb S on paper (pH 8.9) and with Hb A on citrate agar (pH 6.1); it is slower than Hb F on starch gel (pH 8.6)
CHROMATOGRAPHY		Hb X can be isolated from Hb A by cation and anion exchange chromatography
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis; carboxypeptidase B digestion
DNA ANALYSES		Not reported; presumed mutation GGT->CGT; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in a Polish-Canadian family and in a Chinese male from Thailand
OTHER INFORMATION		Quantity in heterozygotes 15-25%

REFERENCES
1.		Vella, F., Casey, R., Lehmann, H., Labossierre, A., and Jones, T.G.: Biochim. Biophys. Acta, 336:25, 1974.
2.		Pootrakul, S., Srichiyanont, S., Wasi, P., and Suanpan, S.: Humangenetik, 23:199, 1974.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.