Hb Oleander	alpha116(GH4)Glu->Gln

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X moves as Hb S at alkaline pH and as Hb A on citrate agar at acidic pH
CHROMATOGRAPHY		Hb X was isolated on a DEAE-Sephadex column
STRUCTURE STUDIES		Tryptic digestion; glycinamidation; cation exchange chromatography; chymotrypsin; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAG->CAG; alpha2 or alpha1
FUNCTIONAL STUDIES		Normal
STABILITY		Normal
OCCURRENCE		Found in a Black family
OTHER INFORMATION		Quantity in the heterozygote 22.3%

REFERENCES
1.		Schneider, R.G., Hightower, B., Carpentieri, U., Duerst, M.L., Shih, T.B., and Jones, R.T.: Hemoglobin, 6:465, 1982.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.