Hb Nunobiki	alpha141(HC3)Arg->Cys

CONTACT		C-terminus
HEMATOLOGY		Mild erythrocytosis in the heterozygote
ELECTROPHORESIS		IEF showed discrete bands of Hb X, Hb A, and Hb A2, in that order
CHROMATOGRAPHY		Hb X and Hb A separate on a DEAE-cellulose column
STRUCTURE STUDIES		Tryptic digestion of alphaX chain; separation of peptides; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CGT->TGT; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in a Japanese male
OTHER INFORMATION		Quantity in the heterozygote 13%; the cysteine residue does not participate in inter- or intra-molecular disulfide formation

REFERENCES
1.		Shimasaki, S.: J. Clin. Invest., 75:695, 1985.

---

This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.