Hb Moabit	alpha86(F7)Leu->Arg

CONTACT		Heme contact
HEMATOLOGY		Mild hemolytic anemia in the heterozygote; reticulocytosis
ELECTROPHORESIS		Hb X moves slightly faster than Hb S on starch block at alkaline pH
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation CTG->CGG; alpha2 or alpha1
FUNCTIONAL STUDIES		Decreased oxygen affinity
STABILITY		Unstable; the Leu->Arg replacement occurs next to the heme binding proximal histidine, greatly affecting the stability of the protein
OCCURRENCE		Found in a Turkish male
OTHER INFORMATION		Quantity in the heterozygote was estimated at about ~15%

REFERENCES
1.		Knuth, A., Pribilla, W., Marti, H.R., and Winterhalter, K.H.: Acta Haematol., 61: 121, 1979.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.