Hb Miyano	alpha41(C6)Thr->Ser

CONTACT		Internal; alpha1beta2 contact
HEMATOLOGY		Erythrocytosis in the heterozygote
ELECTROPHORESIS		Separation of Hb X and Hb A only by IEF
CHROMATOGRAPHY		Hb X and Hb A could not be separated by either anion or cation exchange HPLC
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting on a cation exchange HPLC column; amino acid analysis; acid hydrolysis of the alphaT-6 peptide
DNA ANALYSES		Not reported; presumed mutation ACC->TCC or AGC; alpha2 or alpha1
FUNCTIONAL STUDIES		Increased oxygen affinity
STABILITY		Normal
OCCURRENCE		Found in a Japanese male blood donor, born in 1931
OTHER INFORMATION		None

REFERENCES
1.		Ohba, Y., Imai, K., Uenaka, R., Ami, M., Fujisawa, K., Itoh, K., Hirakawa, K., and Miyaji, T.: Hemoglobin, 13:637, 1989.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.