Hb Memphis | alpha23(B4)Glu->Gln |
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CONTACT | External | ||
HEMATOLOGY | Not reported | ||
ELECTROPHORESIS | Hb X moves to the position of Hb S at both alkaline and acidic pH; it moves slightly cathodal to Hb S on agar gel at pH 6.2 and 7.2 | ||
CHROMATOGRAPHY | Not studied in detail | ||
STRUCTURE STUDIES | Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis | ||
DNA ANALYSES | Not reported; presumed mutation GAG->CAG; alpha2 or alpha1 | ||
FUNCTIONAL STUDIES | Not reported | ||
STABILITY | Not reported | ||
OCCURRENCE | Found in a few Black families | ||
OTHER INFORMATION | Found in combination with Hb S and Hb C; combination with the Hb S condition might be milder than the common sickle cell anemia |
REFERENCES | |||
1. | Kraus, A.P., Miyaji, T., Iuchi, I., and Kraus, L.M.: J. Lab. Clin. Med., 66:886, 1965. | ||
2. | Kraus, L.M., Miyaji, T., Iuchi, I., and Kraus, A.P.: Biochemistry, 5:3701, 1966. | ||
3. | Cooper, M.R., Kraus, A.P., Felts, J.H., Ramseur, W.L., Myers, R., and Kraus, L.P.: Am. J. Med., 55:535, 1973. |