Hb Melusine	alpha114(GH2)Pro->Ser

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		No separation except by IEF; Hb X moves slightly slower than Hb A
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		The alphaA and alphaX chain separates by reversed phase HPLC; the tryptic peptides of the AE-alphaX chain were separated by HPLC methodology; the alphaT-12B peptide was digested with S. aureus V8 protease; HPLC methodology; amino acid analysis; electro-spray mass spectrometry
DNA ANALYSES		Not reported; presumed mutation CCC->TCC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in an Algerian male
OTHER INFORMATION		The alphaX chain has a high hydrophobicity; quantity in the heterozygote is unknown

REFERENCES
1.		Wajcman, H., Kalmés, G., Groff, P., Promé, D., Riou, J., and Galacteros, F.: Hemoglobin, 17:397, 1993.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.