Hb Luxembourg	alpha24(B5)Tyr->His

CONTACT		Internal
HEMATOLOGY		Mild hemolysis; reticulocytosis; no anemia in the heterozygote
ELECTROPHORESIS		Hb X migrates with a pI similar to Hb A1c on IEF
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting on an HPLC column; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation TAT->CAT; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Slightly unstable
OCCURRENCE		Found in two Dutch families
OTHER INFORMATION		Quantity in the heterozygote estimated at 20-22%

REFERENCES
1.		Groff, P., Galacteros, F., Kalmes, G., Blouquit, Y., and Wajcman, H.: Hemoglobin, 13:429, 1989.
2.		Moo-Penn, W.F., Hine, T.K., Johnson, M.H., Jue, D.L., Piersma, H., Therrell, B., Jr., and Chu, A.: Hemoglobin, 15:97, 1991.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.