Hb Lisbon	alpha23(B4)Glu->Asp

CONTACT		External
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		The best separation of Hb X and Hb A is by IEF; the electrophoretic pattern showed a slight decrease in pI
CHROMATOGRAPHY		Not reported
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting on an HPLC column; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAG->GAT; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Not reported
OCCURRENCE		Found in a 31-year-old Portuguese male
OTHER INFORMATION		Quantity in the heterozygote not reported

REFERENCES
1.		Wajcman, H., Bost, M., Blouquit, Y., Préhu, C., Riou, J., and Galacteros, F.: Hemoglobin, 18:427, 1994.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.