Hb Lille	alpha74(EF3)Asp->Ala

CONTACT		External; near central cavity
HEMATOLOGY		Normal in the heterozygote
ELECTROPHORESIS		Hb X and Hb A separate at alkaline pH; Hb X moves to the position of Hb S on cellulose acetate
CHROMATOGRAPHY		Hb X was isolated on a DEAE-cellulose column
STRUCTURE STUDIES		Tryptic digestion; separation of peptides by fingerprinting; amino acid analysis
DNA ANALYSES		Not reported; presumed mutation GAC->GCC; alpha2 or alpha1
FUNCTIONAL STUDIES		Not reported
STABILITY		Normal
OCCURRENCE		Found in an Algerian female
OTHER INFORMATION		Quantity in the heterozygote reported as 34%

REFERENCES
1.		Djoumessi, S., Rousseaux, J., Descamps, J., Goudemand, M., and Dautrevaux, M.: Hemoglobin, 5:475, 1981.

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This material is from the book A Syllabus of Human Hemoglobin Variants (1996) by Titus H.J. Huisman, Marianne F.H. Carver, and Georgi D. Efremov, published by The Sickle Cell Anemia Foundation in Augusta, GA, USA. Copyright © 1996 by Titus H.J. Huisman. All rights reserved. Neither this work nor any part may be reproduced or transmitted in any form or by any means, electronic or mechanical, microfilming and recording, or by any information storage and retrieval systems, without written permission.